Spray your slow cooker with non-stick cooking spray.
In a large bowl, mix together cream cheese, sour cream, both cheeses, diced jalapeños, half the bacon, and garlic powder until well combined.
Transfer mixture to slow cooker and spread evenly.
Cover and cook on LOW for 1.5 to 2 hours, stirring once halfway through, until hot and bubbly.
About 15 minutes before serving, sprinkle panko breadcrumbs and remaining bacon on top. Leave lid slightly ajar to let breadcrumbs crisp up a bit.
Switch to WARM setting and serve with tortilla chips or crackers. Give it a stir every so often to keep it creamy!