Preheat oven to 375°F. Grease a 9x13-inch baking dish with cooking spray.
In a large bowl, combine shredded chicken, frozen vegetables (no need to thaw!), cream of chicken soup, sour cream, cheese, garlic powder, onion powder, salt, and pepper. Mix well until everything is evenly combined.
Spread the chicken mixture evenly in the prepared baking dish.
Separate the biscuits and cut each one into quarters. Arrange the biscuit pieces on top of the chicken mixture, spacing them evenly.
Bake uncovered for 30-35 minutes, until the filling is bubbly around the edges and the biscuits are golden brown on top.
Let cool for 5 minutes before serving. This pairs perfectly with a simple side salad or some buttered corn!