Preheat your oven to 425°F and line a large baking sheet with parchment paper.
In a microwave-safe bowl, combine 2 cups mozzarella cheese and cream cheese, and microwave for 1 minute, then stir and microwave for another 30 seconds until completely melted.
Add the almond flour, egg, Italian seasoning, and garlic powder to the melted cheese mixture and stir vigorously until a dough forms.
Place the dough on the prepared baking sheet and cover with another piece of parchment paper, then roll or press it out into a large circle about 1/4 inch thick.
Remove the top parchment and pre-bake the crust for 8-10 minutes until it just begins to turn golden.
Remove from oven, spread the pizza sauce evenly over the crust, then top with remaining mozzarella cheese, pepperoni, and Parmesan cheese.
Return to the oven and bake for an additional 10-12 minutes until the cheese is melted and bubbly and the edges are golden brown.
Let cool for 5 minutes before slicing and serving.