Preheat oven to 350°F. Cook macaroni according to package directions until al dente, drain, and set aside.
In a large pot, melt 6 tablespoons butter over medium heat. Whisk in flour and cook for 1-2 minutes, stirring constantly, until mixture is golden and bubbly.
Gradually whisk in whole milk and evaporated milk, stirring constantly until sauce thickens, about 5-7 minutes. Add salt, pepper, and garlic powder.
Remove from heat and stir in cheddar, Gruyere, and mozzarella cheeses until completely melted and smooth. Fold in the cooked macaroni until well coated.
Pour mixture into a greased 9x13-inch baking dish. Combine panko breadcrumbs with melted butter and sprinkle evenly over the top. Bake for 25-30 minutes until bubbly and golden brown on top.