Preheat oven to 400°F. Line a baking sheet with parchment paper.
Whisk flour, sugar, baking powder, and salt. Cut in cold butter with a pastry cutter or your fingertips until the mixture looks like rough crumbs.
Stir in cream, egg, orange zest, and cranberries until a shaggy dough forms.
Turn dough onto a floured surface and press into a 1-inch thick disk. Cut into 8 wedges.
Brush tops with cream. Bake for 16 to 18 minutes until golden.
Whisk powdered sugar and orange juice into a glaze and drizzle over cooled scones.