Preheat oven to 350°F and grease a 9x13-inch baking dish.
Cook pasta according to package directions until al dente, then drain and return to pot.
Stir in the cream soup, frozen vegetables, canned protein, 1.5 cups of cheese, garlic powder, Italian seasoning, salt, and pepper until well combined.
Pour mixture into prepared baking dish and spread evenly.
Mix crushed crackers with melted butter and remaining 1/2 cup cheese, then sprinkle over the top.
Bake for 30-35 minutes until bubbly around the edges and topping is golden brown.
Let stand 5 minutes before serving.